My research program focuses on using natural product biosynthetic pathways to uncover unknown areas of chemical diversity and discover potential therapeutics. Natural products remain an exemplary source for therapeutics. In 2014, 25% of approved small-molecule drugs were natural products or derived from natural products. We envision our contribution to modern pharmacognosy as a multidisciplinary area of research that encompasses advanced microbiology to culture and cultivate non-typical bacteria, molecular biology to extract and exploit biosynthetic pathways from bacterial genomes, biochemistry to isolate and investigate enzymes from discovered biosynthetic pathways, and chemistry to appreciate and access the amazing chemical diversity supplied by Nature. In particular my group has a specific interest in natural products from “uncultivable” or “difficult” bacteria, as these are a yet untapped reservoir of new bioactive natural products. Students participating in our group will develop a diverse skill set and become independent researchers capable of working with bacterial natural products from genomic characterization to isolated molecule.