Our research questions and explores the utility provided by specialized metabolites to the producing organism. What do natural products do? The simplicity about this question belies its complexity. While the therapeutic activities of bacterial natural products have driven broad, activity-based discovery efforts, the benefits that the majority of secondary metabolites provide to producing bacteria have been obfuscated by their clinical applications and successes. Investigating the predatory capabilities of myxobacteria, we seek to determine the exchange of specialized metabolites amongst microbes during predation. Developing predator-prey pairings with ecologically relevant prey, we hope to learn how myxobacteria have evolved to combat bacterial behaviors pertinent to clinical concerns such as biofilm formation and persistence.